| 1 | Spider-Man: Brand New Day | 2026-07-29 | $225M | $936.77M | 4.16 |
| 2 | Avengers: Endgame | 2019-04-24 | $356M | $918.37M | 2.58 |
| 3 | Spider-Man: No Way Home | 2021-12-15 | $200M | $864.8M | 4.32 |
| 4 | Black Panther | 2018-02-13 | $200M | $725.26M | 3.63 |
| 5 | Avengers: Infinity War | 2018-04-25 | $300M | $717.82M | 2.39 |
| 6 | Deadpool & Wolverine | 2024-07-24 | $200M | $675.25M | 3.38 |
| 7 | Avengers: Age of Ultron | 2015-04-22 | $365M | $483.6M | 1.32 |
| 8 | Black Panther: Wakanda Forever | 2022-11-09 | $250M | $481.83M | 1.93 |
| 9 | Captain Marvel | 2019-03-06 | $152M | $447.53M | 2.94 |
| 10 | Doctor Strange in the Multiverse of Madness | 2022-05-04 | $200M | $447.33M | 2.24 |
| 11 | Captain America: Civil War | 2016-04-27 | $250M | $433.08M | 1.73 |
| 12 | Wonder Woman | 2017-05-30 | $149M | $423.56M | 2.84 |
| 13 | Guardians of the Galaxy Vol. 2 | 2017-04-19 | $200M | $406.81M | 2.03 |
| 14 | Spider-Man: Across the Spider-Verse | 2023-05-31 | $100M | $398.94M | 3.99 |
| 15 | Spider-Man: Far From Home | 2019-06-28 | $160M | $391.36M | 2.45 |
| 16 | The Batman | 2022-03-01 | $185M | $390.95M | 2.11 |
| 17 | Superman | 2025-07-09 | $225M | $376.68M | 1.67 |
| 18 | Guardians of the Galaxy Vol. 3 | 2023-05-03 | $250M | $376.5M | 1.51 |
| 19 | Deadpool | 2016-02-09 | $58M | $375.74M | 6.48 |
| 20 | Thor: Love and Thunder | 2022-07-06 | $250M | $372.26M | 1.49 |
| 21 | Batman v Superman: Dawn of Justice | 2016-03-23 | $250M | $358.06M | 1.43 |
| 22 | Spider-Man: Homecoming | 2017-07-05 | $175M | $349.97M | 2.00 |
| 23 | Suicide Squad | 2016-08-03 | $175M | $345.6M | 1.97 |
| 24 | Aquaman | 2018-12-07 | $160M | $344.06M | 2.15 |
| 25 | Deadpool 2 | 2018-05-10 | $110M | $343.06M | 3.12 |
| 26 | Thor: Ragnarok | 2017-10-02 | $180M | $329.56M | 1.83 |
| 27 | The Fantastic Four: First Steps | 2025-07-23 | $200M | $298.69M | 1.49 |
| 28 | Doctor Strange | 2016-10-25 | $180M | $242.04M | 1.34 |
| 29 | Justice League | 2017-11-15 | $300M | $242.02M | 0.81 |
| 30 | Logan | 2017-02-28 | $97M | $235.76M | 2.43 |
| 31 | Shang-Chi and the Legend of the Ten Rings | 2021-09-01 | $150M | $233.34M | 1.56 |
| 32 | Ant-Man and the Wasp: Quantumania | 2023-02-15 | $388M | $232.01M | 0.60 |
| 33 | Ant-Man and the Wasp | 2018-07-04 | $140M | $228.15M | 1.63 |
| 34 | Venom: Let There Be Carnage | 2021-09-30 | $110M | $225.09M | 2.05 |
| 35 | Venom | 2018-09-28 | $116M | $223.51M | 1.93 |
| 36 | Captain America: Brave New World | 2025-02-12 | $180M | $212.5M | 1.18 |
| 37 | Thunderbolts* | 2025-04-30 | $180M | $201.77M | 1.12 |
| 38 | Black Widow | 2021-07-07 | $200M | $196.85M | 0.98 |
| 39 | Spider-Man: Into the Spider-Verse | 2018-12-06 | $90M | $193.67M | 2.15 |
| 40 | Ant-Man | 2015-07-14 | $130M | $184.75M | 1.42 |
| 41 | Black Adam | 2022-10-19 | $200M | $175.75M | 0.88 |
| 42 | Eternals | 2021-11-03 | $200M | $174.37M | 0.87 |
| 43 | X-Men: Apocalypse | 2016-05-18 | $178M | $163.35M | 0.92 |
| 44 | Venom: The Last Dance | 2024-10-22 | $120M | $148.26M | 1.24 |
| 45 | Shazam! | 2019-03-29 | $80M | $146.27M | 1.83 |
| 46 | Aquaman and the Lost Kingdom | 2023-12-20 | $205M | $128.98M | 0.63 |
| 47 | Teenage Mutant Ninja Turtles: Mutant Mayhem | 2023-07-31 | $75M | $122.46M | 1.63 |
| 48 | The Flash | 2023-06-13 | $220M | $117.83M | 0.54 |
| 49 | The Marvels | 2023-11-08 | $275M | $91.1M | 0.33 |
| 50 | Birds of Prey (and the Fantabulous Emancipation of One Harley Quinn) | 2020-02-05 | $75M | $88.16M | 1.18 |